Bacterial Genomics and Epidemiology

  • Funding:
    • National Library of Medicine, NIH, grant R01LM009494, titled "Evolutionary analysis of bacterial genomes: High-throughput computational tools."

 

  • Description:
    • In this project, we conduct analyses of bacterial genomes to investigate basic questions in the biology of bacteria (e.g., what is the rate of homologous recombination? what role does horizontal gene transfer plays in the adaptation of bacterial organisms?) and to answer questions of clinical relevance (e.g., how did an infection get transmitted? what mutations resulted in changes to the virulence?). For the basic biological questions, we conduct analyses of publicly available genomic data. These analyses are done in close collaboration with Dr. Hideki Innan and his group in Japan. For the clinical questions, our analyses are currently focused on Staphylococcus aureus isolates obtained from patients, and are done in close collaboration with Drs. James M. Musser and Wesley S. Long from the Methodist Hospital Research Institute in Houston, TX.

 

  • People:
    • Luay Nakhleh (PI)
    • Matt Barnett (research application developer)
    • Cuong Than (former PhD student)
    • Dingqiao Wen (PhD student)
    • Wanding Zhou (former PhD student)

 

  • Publications:
    • Group publications related to this project: click here.