Journal Article
D. Ruths, Muller, M., Tseng, J. T., Nakhleh, L., and Ram, P. T.,
“The Signaling Petri Net-based Simulator: A Non-parametric Strategy for Characterizing the Dynamics of Cell-specific Signaling Networks”,
PLoS Computational Biology, vol. 4, p. e1000005, 2008.
H. Zafar, Tzen, A., Navin, N., Chen, K., and Nakhleh, L.,
“SiFit: A method for inferring tumor trees from single-cell sequencing data under finite-site models”,
Genome Biology, vol. 18, p. 178, 2017.
ZafarEtAl-GB17.pdf (2.12 MB) H. Zafar, Navin, N., Chen, K., and Nakhleh, L.,
“SiCloneFit: Bayesian inference of population structure, genotype, and phylogeny of tumor clones from single-cell genome sequencing data”,
Genome Research, 2019.
I. A. Kanj, Nakhleh, L., Than, C., and Xia, G.,
“Seeing the trees and their branches in the network is hard”,
Theoretical Computer Science, vol. 401, pp. 153-164, 2008.
D. Wen, Yu, Y., Hahn, M. W., and Nakhleh, L.,
“Reticulate Evolutionary History and Extensive Introgression in Mosquito Species Revealed by Phylogenetic Network Analysis”,
Molecular Ecology, vol. 25, pp. 2361-2372, 2016.
WenEtAl-MolEcol2016.pdf (1.26 MB) D. Ruths and Nakhleh, L.,
“Recombination and phylogeny: effects and detection”,
International Journal on Bioinformatics Research and Applications, vol. 1, pp. 202-212, 2005.
Y. Dotsenko, Coarfa, C., Nakhleh, L., Mellor-Crummey, J., and Roshan, U.,
“PRec-I-DCM3: A Parallel Framework for Fast and Accurate Large Scale Phylogeny Reconstruction”,
International Journal on Bioinformatics Research and Applications, vol. 2, pp. 407-419, 2006.
S. Takuno, Kado, T., Sugino, R. P., Nakhleh, L., and Innan, H.,
“Population genomics in bacteria: A case study of Staphylococcus aureus.”,
Molecular Biology and Evolution, vol. 29, no. 2, pp. 797-800, 2012.
TakunoEtAl-MBE11.pdf (933.28 KB) B. M. E. Moret, Nakhleh, L., Warnow, T., Linder, C. R., Tholse, A., Padolina, A., Sun, J., and Timme, R.,
“Phylogenetic networks: modeling, reconstructibility, and accuracy”,
IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 1, pp. 13–23, 2004.
L. Nakhleh, Ringe, D., and Warnow, T.,
“Perfect Phylogenetic Networks: A New Methodology for Reconstructing the Evolutionary History of Natural Languages”,
LANGUAGE, Journal of the Linguistic Society of America, vol. 81, pp. 382-420, 2005.
G. Jin, Nakhleh, L., Snir, S., and Tuller, T.,
“Parsimony Score of Phylogenetic Networks: Hardness Results and a Linear-time Heuristic”,
IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 6, pp. 495-505, 2009.
G. Saxer, Krepps, M. D., Merkley, E. D., Ansong, C., Kaiser, B. L. Deatherage, Valovska, M. - T., Ristic, N., Yeh, P. T., Prakash, V. P., Leiser, O. P., Nakhleh, L., Gibbons, H. S., Kreuzer, H. W., and Shamoo, Y.,
“Mutations in global regulators lead to metabolic selection during adaptation to complex environments”,
PLoS Genetics, vol. 10, no. 12, p. e1004872, 2014.
SaxerEtAl-PLoSGenetics2014.pdf (1.99 MB) H. Zafar, Wang, Y., Nakhleh, L., Navin, N., and Chen, K.,
“Monovar: single nucleotide variant detection in single cells”,
Nature Methods, vol. 13, no. 6, pp. 505-507, 2016.
ZafarEtAl-NMETH2016.pdf (1.51 MB) L. Nakhleh,
“A metric on the space of reduced phylogenetic networks”,
IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 7, pp. 218-222, 2010.
tcbb-Metric.pdf (287.01 KB)